Academic Supervisor: Professor Jonathan W. Essex, School of Chemistry, University of Southampton.
Industrial Supervisor: Dr Richard A Ward, AstraZeneca, Alderley Park, Macclesfied.
Kinase proteins are intimately involved in cell signalling, and in many cases mutations to these proteins are involved in the development of cancers. A number of small-molecule drugs have been developed to target these proteins, most notably gleevec, which binds to the BCR-ABL kinase and is used as a treatment for chronic myelogenous leukemia, and iressa, which binds to the epidermal growth factor receptor’s (EGFR) tyrosine kinase domain and is used to treat non-small cell lung cancer. However, as is the case for bacteria and viruses, the tumour proteins can mutate and thereby develop resistance to these drugs. The mechanisms by which these mutations confer drug resistance are unclear, and are likely to depend on the particular mutation involved. Clearly, however, if we are able to understand these mechanisms, we are then in a position to design novel inhibitors which are unaffected by these mutations.
In this studentship, you will address the issue of how mutations of EGFR confer drug resistance to kinase inhibitors by using a range of simulation techniques, including docking and scoring, fast free energy calculations, and more accurate rigorous free energy methods. Methods to calculate the relative free energies of different protein conformations will also be used. This studentship is funded by the EPSRC and AstraZeneca (AZ), and will be supported by direct access to relevant experimental data available through AZ. The project will be supervised by Prof Jonathan Essex at the University of Southampton, together with a senior scientist from AZ. You will be joining an established research team working in the area of applying and developing computer simulation methods to biological problems.
Continue reading PhD Studentship in the Computational Investigation of Drug Resistant Mutations in the Kinases, University of Southampton, UK
Postgraduate Studentships in Chemistry
National University of Ireland, Galway
Commencing September/October 2009
Biomolecular Electronics Research Laboratory
Several fully-funded post-graduate Ph.D. studentships in the Biomolecular Electronics Research Laboratory are available, funded under collaborative research awards by the ERA – Chemistry initiative, the EU FP7 programme, and a Charles Parsons Energy Research Award.
1. Preparation, characterization and evaluation of integrated bioelectrocatalytic systems (enzyme-based) for sensor and energy conversion
2. Bioelectrocatalytic (enzyme and microbial) systems for electricity generation
Continue reading PhD Studentships in the Biomolecular Electronics Research Laboratory, National University of Ireland, Galway, Ireland
ESRC PhD Studentship – Exploring the Social Objectives and Impacts of UK Fisheries Policy
The Scottish Government and Centre for Rural Economy at Newcastle University Reference Code: AG001
Closing Date: 26th June 2009
Supervisors: Jeremy Phillipson, Dr Jane Atterton Project duration: 3 years
Project start date: September 2009
This collaborative research project with the Scottish government will explore the meaning, justification and implementation of social objectives within fisheries policy. The research will draw on theories of territorial rural development and multi-level governance and notions of ‘resilience’ and ‘adaptive capacity’. It will consider such questions as: What has been the broad socio-economic impact of recent fisheries policies on Scotland’s fishing communities? How are fisheries and development agencies encouraging resilience and adaptation of fishing communities?
Continue reading PhD Studentship, ESRC / Scottish Government, Exploring the Social Objectives and Impacts of UK Fisheries Policy, UK
The PhD candidate will conduct a study of the design practices of telemonitoring technologies currently developed and implemented in health care in Europe. In your research you will employ and further develop theoretical perspectives of sociology and philosophy of technology concerning the co-construction of users, technologies and norms of care.
You have a master degree in one of the social sciences (technology and culture; philosophy of technology; sociology; or media studies) and affinity with societal problems related to the introduction of ICT in healthcare. You are motivated and able to work independently as well as in collaborative projects.
University of Twente School of Management Governance (MB)
The University of Twente (UT) is an entrepreneurial research university, located in Enschede, the Netherlands. Organized over five faculties, the UT offers twenty educational programs ranging from applied physics, public and business administration, communication studies and diverse programs in engineering technology. Research takes place within the context of institutes and focuses, among other things, on information and communication technology, nanotechnology, biomedical technology, policy studies, construction management & engineering, and mechanics. More than 7,000 students and 2,700 staff members live and work at the UT, the Netherlands’ only campus university.
Continue reading PhD Studentships in Telemonitoring Technologies, University of Twente, The Netherlands
PhD studentship in spintronics, nanomagnetism and magnetic resonance at Forschungszentrum Juelich (FZJ, Germany) in cooperation with Gebze Institute of Technology (GIT, Turkey)
Department of Physics of Gebze Institute of Technology (GIT, Turkey) and Spin-electronics group of Institut für Festkörperforschung (IFF) at Forschungszentrum Juelich (FZJ, Germany) are applying for joint grants for PhD students to conduct research at FZJ and GIT. PhD student(s) will conduct studies of nanomagnetic structures prospective for spintronic applications. The studies will include the preparation of various nanomagnets and probing their dynamic magnetic properties using high-frequency techniques (magnetic resonance).
Funding for 1 or 2 PhD positions may be available upon evaluation by both cooperative parties and the funding agencies of the program. The expected evaluation period is about 3-4 months. Candidates are expected to have a master degree (or to be sure in obtaining MSc before the end of July, 2009). Other requirement is that the candidate which will conduct studies in Germany has to be enrolled (or, at least, to plan an application) for PhD program at GIT (or another Turkish University) with the supervisor from GIT, or vice versa, the candidate intended to conduct studies in Turkey has to be enrolled at German University with PhD thesis supervisor at IFF.
Continue reading PhD Studentships in Spintronics, Nanomagnetism and Magnetic Resonance, Forschungszentrum Juelich, Germany
PhD Programme in Science and Management of Climate Change
CALL for APPLICATION 2009/2010
In 2007, the Department of Economics and the Department of Environmental Sciences of the Università Ca’ Foscari of Venice, in collaboration with the Euro-Mediterranean Center for Climate Change (CMCC), have launched a 3-year PhD Programme in Science and Management of Climate Change.
Every year, up to twelve students are enrolled in this Ph.D. programme. All lectures are given in English by internationally renowned professors.
The PhD Programme is organised into two streams:
- Dynamic Climatology at the CMCC Headquarters in Bologna
- Climate Change Impact and Management, at the Department of Economics of the University Ca’ Foscari of Venice
For the year 2009/2010 (25th cycle of Italian PhD Programmes) we offer three scholarships with the financial support of the Euro-Mediterranean Center for Climate Change.
Continue reading PhD Scholarships in Science and Management of Climate Change, University of Venice, Italy
- Title: Posdoctor position in structural composites with carbon nanotubes
- Working area: Aerospace structures
- FAPESP process: 07/00013-4
- Project title: Structural composites with epoxy resin and dispersion of multiwall carbon nanotube
- Field of knowledge: Aerospace Engineering
- Principal investigator: Evaldo José Corat
- Unit/Instituition: Instituto Nacional de Pesquisas Espaciais
The application of carbon nanotubes in structural composites seeks significant enhancement of its structural, thermal and electrical properties. Even though individual properties of carbon nanotubes are extreme, there are many difficulties in transferring such properties to the composite.
Continue reading Postdoctoral Fellowship in Structural Composites with Carbon Nanotubes, Instituto Nacional de Pesquisas Espaciais, Brazil
The Irish Social Sciences Platform (ISSP) is a collaborative initiative funded by the Programme for Research in Third Level Institutions (PRTLI) which supports research on the social, cultural and economic transformation shaping Ireland in the 21st century. A funded PhD scholarship is available through this scheme in the research area of Geographical Information Systems (GIS) and health, with its research focus on health in Ireland. The research will be supervised by Jan Rigby and Martin Charlton, and based in the new Centre for Health Geoinformatics, in the National Centre for Geocomputation (NCG) at the National University of Ireland Maynooth (www.nuim.ie/ncg).
Scholarship awards are valued at €16,000 per year plus fees (at EU rates) for three years. It is anticipated that the successful candidate will take up the scholarship in September 2009. Applicants should have a good undergraduate degree and, preferably, a master’s qualification in GIS or comparable postgraduate work experience.
Closing date for applications: June 30th, 2009.
Please email a CV and letter outlining your areas of research interest, along with names and contact details of two referees who can comment on your academic suitability to Dr Jan Rigby (jan.rigby[ at ]nuim.ie).
The University of Ferrara offers to international students several PhD positions, three of them with fellowships.
The successful applicants will start their activity on January 1st, 2010. Winners of the fellowships will receive about 1000 Euro net per month and will be entitled to have a room at the Residential College of IUSS-Ferrara 1391 at half of the cost. Additional places without fellowship are foreseen.
For international students, admission to doctoral programs and special fellowships is based on qualifications and letters of recommendation.
The application has to be done on line, at http://studiare.unife.it by July 13 2009 and it should include:
- A photocopy of an identity document
- Certification of the University degree, including titles of the courses and marks obtained in the examinations.
- At least two recommendation letters.
- Curriculum vitae
- A research project of the applicant (max 3 pages)
- Any other document which can be useful for evaluating the attitude of the candidate to the research activity.
Continue reading International Student PhD Fellowships, The University of Ferrara, Italy