PhD Studentship in Vascular Medicine, University of Nottingham, UK

Predictors of responders to non-responders with DPP-IV inhibitor and association between oral antidiabetic use with hypoglycaemia and cardiovascular outcome

Supervisors: Dr Iskandar Idris & Professor Richard Donnelly

Applications are invited from highly motivated individuals for the above studentship, based at the School of Graduate Entry Medicine and Health at the Royal Derby Hospital.

Dipeptidyl peptidase IV (DPP-IV) inhibitor is a novel glucose lowering agent increasingly used in the United Kingdom for the management of hyperglycaemia in patients with type 2 diabetes. Evidence from clinical trials suggest that this class of drugs may offer advantage over other oral glucose lowering therapy due to reduced risks of hypoglycaemia and neutrality effect on patients body weight. Guidelines from the National Institute of Clinical Excellence (NICE) have recommended for DPP-IV inhibitor to be considered as a second or third line drug for patients with type 2 diabetes, particularly where there are concerns about patients risk of weight gain or hypoglycaemia.

Despite this, the uptake of DPP-IV inhibitor in the UK is patchy. This is possibly due to the ongoing uncertainties of the clinical benefits of DPP-IV inhibitor in real world clinical practice as well as its place amongst other more established oral glucose lowering therapies. Evidence from meta-analysis of DPP-IV inhibitor suggests that low baseline HbA1c is the best predictor for achievement of A1c target whilst experimental data has shown DPP-IV inhibitor preserves beta cell mass and function. We would therefore postulate that DPP-IV inhibitor is most affective when introduced early during the course of diabetes. Furthermore, UK ‘real world’ data on the risks of hypoglycaemia between different oral glucose lowering agent which incorporate DPP-IV inhibitor usage is not available. The latter is particularly important given the recent debates about the risks of cardiovascular events in patients with increased risks of hypoglycaemia or with very low HbA1c values. Since diabetes is a progressive disease, combination therapy is widely used to achieve optimal glucose levels. Consequently, studies to investigate the role of individual glucose lowering therapies on their risk of developing CVD events are fraught with significant confounders and treatment bias. Furthermore, such studies do not reflect ‘real world’ medicine where dual, triple or quadruple therapies are often used with or without insulin to achieve target glucose levels.

Utilising data from a well- validated UK primary care electronic database will enable us to gain new insights into the CVD outcomes for different combination glucose lowering therapies, their appropriate place in the guidelines for managing hyperglycaemia in patients with type 2 diabetes as well as the association between oral antidiabetic drugs (OAD), risks of hypoglycaemia, Hba1c levels and adverse cardiovascular outcomes. The major difficulty for observational studies to provide reliable information on cardiovascular events however relates to the ability of primary care research database to balance measured and unmeasured confounders due to not having rigorous inclusion, exclusion criteria and exposure definitions. Several well documented examples exist where results from observational studies were reported to be misleading. To overcome this, we will use a recently validated method enhance the validity of the results.

Students should have, or will expect to attain at least a masters or a degree in either public health, epidemiology or health related sciences. In addition the candidate should have a good understanding of statistics, mathematics or computer science. This studentship is available for a period of 3 years and provides a stipend of £13,590 per annum. Due to funding restrictions this studentship is available to UK/EU citizens only. Non UK/EU citizens are welcome to apply but the grant will not cover the additional international fees.

For further information or for any questions, please contact Dr Iskandar Idris, Iskandar.Idris@nottingham.ac.uk. Please note that applications sent directly to this Email addresses will not be accepted.

Application forms are available from Mrs S Rougeolle, School of Graduate Entry Medicine & Health, University of Nottingham, Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT. Tel: 01332 724618. Email: sue.rougeolle@nottingham.ac.uk.

Reference : MED1126
Closing Date : 30 November 2012

1 Star2 Stars3 Stars4 Stars5 Stars
Please Rate :)
Loading...

Donation

If you find our website useful, please consider making a donation. It will help us pay our operating expenses.


  1. Tuition + Living Allowance Scholarships, University of Waikato, New Zealand
  2. Fully Funded Scholarships, King Fahd University of Petroleum and Minerals, Saudi Arabia
  3. Master Scholarships, Faculty of Medicine, Imperial College London, UK
  4. Fully Funded YSEALI Academic Fellowship, USA
  5. Fully Funded Australia Awards Scholarships
  6. Fully Funded GCE A Level Scholarships for Indonesian Students, Singapore
  7. Fully Funded Master Scholarships, Kyoto University, Japan
  8. Fully Funded Scholarships, Mohamed bin Zayed University of Artificial Intelligence, UAE
  9. Fully Funded Scholarships in Astronomy, University of Cambridge, UK
  10. Full Tuition Fee LLM Scholarships, University of Warwick, UK
  11. Fully Funded Scholarships – Qatar University
  12. Fully Funded Scholarships, Bond University, Australia
  13. Fully Funded Art Major Asian plus Scholarships, Korea National University of Arts, South Korea
  14. Full Funded VLIR-ICP Master Scholarships, KU Leuven, Belgium
  15. Fully Funded Fulbright Distinguished Awards in Teaching Program, USA
  16. Fully Funded Scholarships, Pukyong National University, South Korea
  17. Fully Funded Scholarships, Yeungnam University, South Korea
  18. Fully Funded Scholarships, Sungkyunkwan University, South Korea
  19. Fully Funded Scholarships, Sunchon National University, South Korea
  20. Fully Funded Scholarships, Seoul National University of Science and Technology, South Korea
  21. Fully Funded Scholarships, Pusan National University, South Korea
  22. Fully Funded Scholarships, Kyungpook National University, South Korea
  23. Fully Funded Scholarships, University of New England, Australia
  24. Fully Funded Scholarships, Kunsan National University, South Korea
  25. Fully Funded Scholarships, Kangwon National University, South Korea
  26. Fully Funded Scholarships, Jeonbuk National University, South Korea
  27. Fully Funded Scholarships, Hoseo University, South Korea
  28. Fully Funded Scholarships, Gyeongsang National University, South Korea
  29. Fully Funded Scholarships, Dongseo University, South Korea
  30. Fully Funded Scholarships, Chung-Ang University, South Korea
  31. Fully Funded Scholarships, Chonnam National University, South Korea
  32. Fully Funded Scholarships, Ajou University, South Korea
  33. Fully Funded Graduate Scholarships for International Students, South Korea
  34. Fully Funded Fulbright Foreign Language Teaching Assistant, USA
  35. Fully Funded Scholarships, CERGE-EI, Czech Republic
  36. Full Tuition Fee Scholarships for Female Students from Developing Countries, Swansea University, UK
  37. Master Scholarships, University of Twente, Netherlands
  38. Fully Funded Sport Management Scholarships, Seoul National University, South Korea
  39. Fully Funded ADB JSP Scholarships, Asian Institute of Technology, Thailand
  40. Fully Funded Scholarships in Singapore
  41. Fully Funded Scholarships, Okinawa Institute of Science and Technology, Japan

Commonwealth Scholarships, University of Nottingham, UK
6 FULL Scholarships – tuition fees, airfare, maintenance award and additional allowances The University of Nottingham is delighted to offer this scholarship in partnership with the UK Department for International Development (DFID) and the Association of Commonwealth Universities (ACU) You can apply for this scholarship if you are from one of the eligible

Vice-Chancellor’s Scholarship for Research Excellence, University of Nottingham, UK
Our Vice-Chancellor’s Scholarships for Research Excellence aim to recognise and reward applications from outstanding international students. In 2019 we are offering: full tuition fee scholarships plus a stipend of £7,000 per annum Closing date: 3 May 2019. Who is eligible to apply? You can apply for this scholarship if you: are classed as

MA / MSc Scholarships, Nottingham University Business School, UK
Nottingham University Business School is among the best UK centres for management education. Our faculty are leading researchers in their fields, so you can be sure that our teaching is informed by world-class research. MA Scholarships The Business School is offering up to two full-fee scholarships for the full-time MA Programmes. Home/EU

MSc in Drug Discovery & Pharmaceutical Sciences Scholarship, University of Nottingham, UK
MSc in Drug Discovery and Pharmaceutical Sciences in the School of Pharmacy. The School of Pharmacy is proud to announce it will be running this new course from September 2013 and to celebrate the inaugural year of the course five full tuition fee scholarships are being offered for exceptional candidates. More

MBA Scholarships, Nottingham University Business School, UK
For the 2011/12 programme, the School is offering a number of scholarships for the Nottingham MBA. The School will only consider you eligible for a scholarship once you have been offered a place on the programme and have accepted your place by paying the course deposit. Nottingham

Nottingham University Business School Scholarships, UK
Nottingham University Business School is currently inviting applications for PhD scholarships from candidates starting their studies in October 2018. The scholarships available will be project based and in the following areas: Accounting Centre for Health Innovation Leadership and Learning (CHILL) Haydn Green Institute of Entrepreneurship and Innovation (HGI) Industrial Economics

MA Scholarships in Politics & International Relations, University of Nottingham, UK
Each scholarship amounts to a £1000 reduction in fees for students (home/EU or international) on one of the taught MA programmes currently running in the School of Politics and International Relations. Please note that to be eligible for the scholarships: Applicants must hold an offer to study on a taught MA programme

International Baccalaureate Diploma Excellence Scholarship, University of Nottingham, UK
Be inspired and achieve your ambitions with scholarships from £2,500 up to £15,000 towards your tuition fees. The University of Nottingham is consistently ranked among the world's top 100 universities* and is ranked 8th in the UK for research power**. Applications for this scholarship in the 2019/20 academic year are now open. About

Anne McLaren Fellowships 2011, University of Nottingham, UK
Applications are invited for the above fellowships, which are targeted at exceptional female scientists and engineers who are typically under-represented in these subjects, and wish to establish a research career in the UK. The Fellowships are a recognized first step into an independent research career, and are

ASEAN Master Scholarships, University of Nottingham, UK
The University of Nottingham is consistently ranked among the world's top 100 universities* and is ranked 8th in the UK for research power**. In 2019 we are offering scholarships of 25% towards tuition fees for students from ASEAN member countries. Closing date 17 May 2019. Who is eligible to apply? You can apply for

Disclaimer: Every effort has been made to ensure the above information is current and correct. However, applicants should contact the appropriate administering body before making an application, as details do change frequently.

One thought on “PhD Studentship in Vascular Medicine, University of Nottingham, UK”

Comments

css.php