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Especially rodents, mainly )] TJ ET BT 60.000 460.002 Td /F1 9.0 Tf [(mouse and rat, are often used for this purpose, as well as for pre-clinical trials of new drugs and toxicology screens. )] TJ ET BT 60.000 449.013 Td /F1 9.0 Tf [(However, often animal models fail to mimic human disease adequately. As a consequence drugs successfully tested )] TJ ET BT 60.000 438.024 Td /F1 9.0 Tf [(in animal models fail in costly clinical trials or are falsely discarded. Goal of this project is to explore the suitability of )] TJ ET BT 60.000 427.035 Td /F1 9.0 Tf [(rodents as a model organism for human disease, specifically metabolic syndrome. Since metabolic syndrome is a )] TJ ET BT 60.000 416.046 Td /F1 9.0 Tf [(complex multifactorial group of metabolic conditions, a systems approach will be taken to uncover the molecular )] TJ ET BT 60.000 405.057 Td /F1 9.0 Tf [(networks perturbed by disease. Specifically, we aim to validate the similarity of a large number of rodent models for )] TJ ET BT 60.000 394.068 Td /F1 9.0 Tf [(metabolic syndrome to their human counterparts. The project is tightly linked to ongoing projects in biological and )] TJ ET BT 60.000 383.079 Td /F1 9.0 Tf [(clinical groups at the AMC. This project is part of the second round of the BioRange programme of the Netherlands )] TJ ET BT 60.000 372.090 Td /F1 9.0 Tf [(Bioinformatics Centre \(NBIC; www.nbic.nl\).)] TJ ET BT 60.000 351.101 Td /F2 9.0 Tf [(Tasks)] TJ ET BT 60.000 340.112 Td /F1 9.0 Tf [(The successful candidate will work towards a PhD degree in bioinformatics. We will build a compendium of rodent )] TJ ET BT 514.662 340.112 Td /F1 9.0 Tf [(and )] TJ ET BT 60.000 329.123 Td /F1 9.0 Tf [(human metabolic syndrome related gene expression datasets. We develop module-based joint analysis methods that )] TJ ET BT 60.000 318.134 Td /F1 9.0 Tf [(search for conserved patterns consisting of sets of genes and sets of conditions in both rodent model and human )] TJ ET BT 60.000 307.145 Td /F1 9.0 Tf [(under which they are co-expressed. These patterns are used to evaluate the molecular similarity of rodent models and )] TJ ET BT 60.000 296.156 Td /F1 9.0 Tf [(their human counterpart. Conserved patterns will be further interpreted by constructing functional networks for )] TJ ET BT 60.000 285.167 Td /F1 9.0 Tf [(metabolic syndrome in rodents and human. 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Based on a full-time appointment \(36 )] TJ ET BT 60.000 134.288 Td /F1 9.0 Tf [(hours per week\), compensation will be according to standard salary levels for PhD students starting with a salary of € )] TJ ET BT 60.000 123.299 Td /F1 9.0 Tf [(2046,- with a yearly growth to € 2622,- gross a month. The collective employment agreement of the AMC is )] TJ ET BT 60.000 112.310 Td /F1 9.0 Tf [(applicable. Additional information about the vacancy can be obtained from:)] TJ ET BT 60.000 91.321 Td /F1 9.0 Tf [(Dr. ir. P.D. Moerland)] TJ ET BT 60.000 80.332 Td /F1 9.0 Tf [(Bioinformatics Laboratory)] TJ ET endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Annot /Subtype /Link /A 11 0 R /Border [0 0 0] /H /I /Rect [ 242.2490 756.8743 348.2490 765.8743 ] >> endobj 11 0 obj << /Type /Action /S /URI /URI (https://beasiswaindo.com) >> endobj 12 0 obj << /Type /Page /Parent 3 0 R /Annots [ 14 0 R 16 0 R 18 0 R 20 0 R 22 0 R 24 0 R 26 0 R 28 0 R 30 0 R 32 0 R 34 0 R 36 0 R 38 0 R 40 0 R 42 0 R 44 0 R 46 0 R 48 0 R 50 0 R 52 0 R 54 0 R 56 0 R 58 0 R 60 0 R 62 0 R 64 0 R 66 0 R 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 78 0 R 80 0 R 82 0 R 84 0 R 86 0 R 88 0 R 90 0 R 92 0 R 94 0 R 96 0 R 98 0 R 100 0 R 102 0 R 104 0 R 106 0 R 108 0 R 110 0 R 112 0 R 114 0 R 116 0 R ] /Contents 13 0 R >> endobj 13 0 obj << /Length 9562 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