Postdoctoral Research Fellow (Dr Anna-Marie Fairhurst’s Lab)
Job Reference No: SIgN/AMF/131209
Postdoc positions in the lab of Dr. Anna-Marie Fairhurst, Singapore Immunology Network (SIgN)
Description
The overall goal of the lab is to determine the innate mechanisms which drive pathogenic autoimmunity.
Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease that is classically associated with the production of pathogenic autoantibodies to a wide spectrum of nuclear antigens. This leads to an immune complex deposition of self-reactive material culminating with cellular recruitment, cytokine production and overall inflammation within organs such as the kidney. Our recent and ongoing investigations into the functional variations of several SLE susceptibility loci, including Yaa and Sle3, have demonstrated that these disease alleles enhance responses to TLR ligands and mediate myeloid cell hyperactivity.
Each project will determine the mechanism by which TLR7 and TLR9 augment autoimmunity. There will be additional opportunities for motivated postdocs to work “hands on” with collaborators in the US.
Continue reading Postdoctoral Research Fellow, Singapore Immunology Network (SIgN), Singapore